Gregory Shearer, PhD

photo of Gregory Shearer

Associate Professor

Contact Information

110 Chandlee Lab
University Park PA 16802

814-867-3040

(fax) 814-863-6103

gcs13@psu.edu

Research Interests

Lipid mediators are bioactive metabolites of dietary fatty acids. They act on tissues to alter many disease-related functions, including the stiffness of blood vessels and the body's response to stress.

Most investigations focus on the actions of individual lipid mediators, however over-nutrition and the stress of "western diets" is characterized by a global shift of dietary fatty acids, not a shift in any single fatty acid. The consequence of multiple changes in fatty acids is a corresponding change in the array of lipid mediators produced. We seek to understand disease-related functional changes in the context of globally changes and use them to identify markers of disease and better ways to prevent or manage disease.